After the completion of the human genome project in the early 2000’s, a next goal of the genomics community is to reach the so-called “thousand dollar genome”. Over the past few years, both the cost and the time required to sequence an entire human genome have been dramatically cut by several orders of magnitude. Major challenges, however remain. These include the acquisition, management and analysis of terrabytes of image and sequence data, quality control and error assessment, data compression, variant identification, disease association analysis, and so on.
We have collaborated with groups from Arizona (TGen, University of Arizona, DMetrix, Biodesign) and other institutions around the country to develop improved technologies and informatics that can move us toward the goal of faster and cheaper genomics sequencing.
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